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White Blood Cells and Differential for Those with CLL / SLL
By Susan J. Leclair, PhD, CLS (NCA) The WBC on your CBC report is the total number of white cells found in a volume of blood. In the U.S. it is usually 1 microliter (µL) while in other parts of the...
View ArticleiwCLL 2019: Dr. Danilov Discusses the Role of B-cells and T-cells in CLL...
In this video, Dr. Alexey Danilov, M.D., Ph.D., a chronic lymphocytic leukemia (CLL) specialist, now at the City of Hope Comprehensive Cancer Center in Duarte, California, is interviewed by CLL Society...
View ArticleASH 2020: Dr. Adrian Wiestner on Early Detection of BTK Mutations Preceding...
Bruton’s tyrosine kinase (BTK) is a key signaling molecule involved in the survival of malignant B cells. Drugs that inhibit the action of BTK block the signals that allow malignant cells to grow...
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iwCLL 2019: Dr. Carlo Croce on the Role of MicroRNA in Chronic Lymphocytic...
Gene expression is a key concept in biology. Basically, our DNA contains genes which provide the instructions for making proteins (the molecules responsible for carrying out the actual functions of our...
View ArticleASH 2020: Dr. Alexey Danilov on the Chronic Lymphocytic Leukemia (CLL)...
While having chronic lymphocytic leukemia (CLL) can feel like more than enough to deal with on its own, many patients also have other ongoing health conditions that need management. These additional...
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Introduction to Immunity
By Susan J. Leclair, PhD, CLS (NCA) This is a general introduction to one of the ways that your immune system tries to protect you. I have combined and simplified a fair number of steps in order to...
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Introduction to Immunity Part 2
By Susan J. Leclair, PhD, CLS (NCA) Specific Response or Adaptive Immunity In this article we will review the specific defense system or the immune response. For those of you who like history, this...
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Introduction to Immunity Part 3
By Susan J. Leclair, PhD, CLS (NCA) This article will repeat some of the earlier material, but you can still go back and reread them from past CLL Society Tribune editions, Introduction of Immunity...
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Introduction to Immunity Part 4: Testing
By Susan J. Leclair, PhD, CLS (NCA) What tests to do? With an overall understanding of how the system functions, we can look at what testing can be done and what it can tell us. As the immune system...
View ArticleASH 2022: Effects of Acalabrutinib on T Cells in CLL
Medically reviewed by Dr. Brian Koffman The Bottom Line: Blood samples from patients participating in a phase 2 clinical trial of acalabrutinib and obinutuzumab suggest that acalabrutinib treatment...
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